Understanding how infections change blood vessel surfaces in sepsis
PROJECT 3 - Infection-Induced Remodeling of the Vascular Proteome
This research looks at how severe infections like sepsis change the surface of blood vessels and how these changes affect the body's response and survival.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sanford Burnham Prebys Medical Discovery Institute NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11110319 on NIH RePORTER |
What this research studies
When the body has a severe infection, like sepsis, the surfaces of blood vessels can change, leading to problems with blood clotting and inflammation. This project aims to understand exactly what these changes are and how they impact the body's ability to fight the infection and recover. Researchers are using advanced methods to map out the proteins and sugars on blood vessel surfaces in different organs during infection. This work helps us discover new markers and factors that play a role in how the body responds to severe infections.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients but aims to benefit those who suffer from severe infections and sepsis, especially those experiencing blood coagulation disorders.
Not a fit: Patients not experiencing severe infections or sepsis-related complications would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to identify and treat the dangerous blood clotting and inflammation associated with sepsis, potentially improving patient outcomes.
How similar studies have performed: Previous work has shown that sepsis causes changes in blood components and vessel surfaces, and this project builds on those findings by investigating the specific composition of these changes.
Where this research is happening
La Jolla, United States
- Sanford Burnham Prebys Medical Discovery Institute — La Jolla, United States (Active)
Researchers
- Principal investigator: Esko, Jeffrey D — Sanford Burnham Prebys Medical Discovery Institute
- Study coordinator: Esko, Jeffrey D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.