Understanding how infections and cancer affect immune cell metabolism
A Predictive Modeling Framework to Dissect the Dynamic Immunometabolic Responses to Pathogenic infection and the Kinetic Reprogramming of Metabolism in Cancer Cell System
This study is looking at how infections like COVID-19 and cancer affect the way immune cells use energy, which could help us understand how to better support your immune system during these challenges.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Lincoln NIH-funded |
| Lab location | 1 site (Lincoln, United States) |
| Project ID | NIH-10891648 on NIH RePORTER |
What this research studies
This research investigates how infections, particularly COVID-19, and cancer influence the metabolism of immune cells. By developing a predictive modeling framework, the study aims to analyze the dynamic changes in immune responses and metabolic shifts in cells during pathogenic infections. The approach combines various scales of biological modeling to create a comprehensive understanding of these processes, which could lead to new therapeutic strategies. Patients may benefit from insights into how their immune systems respond to infections and cancer at a metabolic level.
Who could benefit from this research
Good fit: Ideal candidates include patients with COVID-19 or various types of cancer who are interested in understanding the metabolic aspects of their conditions.
Not a fit: Patients with stable, non-infectious conditions or those not affected by cancer may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to novel therapies that enhance immune responses against infections and cancer.
How similar studies have performed: Other research has shown promise in understanding immune responses through metabolic modeling, but this approach aims to provide a more comprehensive and integrated framework.
Where this research is happening
Lincoln, United States
- University of Nebraska Lincoln — Lincoln, United States (Active)
Researchers
- Principal investigator: Saha, Rajib — University of Nebraska Lincoln
- Study coordinator: Saha, Rajib
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.