Understanding how infections affect brain development in children with hydrocephalus
Disease Mechanisms of Prenatal and Pediatric Acquired Hydrocephalus
This study looks at how bacterial and viral infections might lead to hydrocephalus in kids by affecting important brain cells, and it aims to understand how this damage happens and how we might be able to fix it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Connecticut Storrs NIH-funded |
| Lab location | 1 site (Storrs-Mansfield, United States) |
| Project ID | NIH-10802185 on NIH RePORTER |
What this research studies
This research investigates the impact of bacterial and viral infections on the development of hydrocephalus in children. It focuses on how these infections can damage the brain's protective ependymal cells, which are crucial for maintaining the health of the brain's stem cell niche. By modeling these infections, the research aims to understand the mechanisms of damage and potential repair in the brain's ventricular system. This study utilizes advanced imaging techniques and lineage tracing to analyze changes in brain structure and function over time.
Who could benefit from this research
Good fit: Ideal candidates for this research include children diagnosed with hydrocephalus, particularly those with a history of infections.
Not a fit: Patients who do not have hydrocephalus or a related history of infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and preventive strategies for children affected by hydrocephalus due to infections.
How similar studies have performed: Previous research has shown promising results in understanding the effects of infections on brain development, indicating that this approach has potential for success.
Where this research is happening
Storrs-Mansfield, United States
- University of Connecticut Storrs — Storrs-Mansfield, United States (Active)
Researchers
- Principal investigator: Conover, Joanne C — University of Connecticut Storrs
- Study coordinator: Conover, Joanne C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.