Understanding how infants and children develop immunity to HIV-1
Neonatal Immunity to novel TF SHIVs
This study is looking at how babies and kids with HIV-1 can make special antibodies better than adults, and it hopes to use what they learn to help create better vaccines for children with the virus.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-11056121 on NIH RePORTER |
What this research studies
This research investigates how infants and children living with HIV-1 produce broadly neutralizing antibodies (bnAbs) more effectively than adults. By studying the cellular and molecular mechanisms behind this process, the research aims to enhance our understanding of pediatric HIV-1 immunity. The team uses a chimeric simian-human immunodeficiency virus (SHIV) model to observe the immune responses in neonate rhesus macaques, which may provide insights applicable to human pediatric populations. The findings could inform the design of vaccines specifically tailored for children with HIV-1.
Who could benefit from this research
Good fit: Ideal candidates for this research include infants and children diagnosed with HIV-1.
Not a fit: Patients who are adults or those without HIV-1 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved vaccine strategies for children living with HIV-1, enhancing their immune response and health outcomes.
How similar studies have performed: Previous research has shown promising results in understanding pediatric immunity to HIV-1, indicating that this approach has potential for success.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Williams, Wilton B — Duke University
- Study coordinator: Williams, Wilton B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.