Understanding how individual neurons encode sleep and wake states
The Sleep Signature: A Disentangled State in Each Neuron
['FUNDING_FELLOWSHIP'] · WASHINGTON UNIVERSITY · NIH-10900364
This study is looking at how brain cells work during sleep and wakefulness to help us understand sleep better, which could be useful for people with conditions like Alzheimer's and autism.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WASHINGTON UNIVERSITY (nih funded) |
| Locations | 1 site (SAINT LOUIS, UNITED STATES) |
| Trial ID | NIH-10900364 on ClinicalTrials.gov |
What this research studies
This research investigates how individual neurons in the brain encode different states of sleep and wakefulness. By analyzing fast neuronal spike patterns, the study aims to uncover the unique ways that each neuron contributes to our understanding of sleep. The approach involves using microelectrode recordings and machine learning techniques to disentangle the influences of various factors on neuronal activity. This could lead to a deeper understanding of sleep mechanisms and their implications for conditions like Alzheimer's disease and autism.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with sleep disorders, Alzheimer's disease, or autism spectrum disorders.
Not a fit: Patients without any sleep-related issues or neurological conditions may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of sleep disorders and lead to improved treatments for conditions such as Alzheimer's disease and autism.
How similar studies have performed: Other research has shown promising results in understanding neuronal activity patterns, suggesting that this approach could yield valuable insights.
Where this research is happening
SAINT LOUIS, UNITED STATES
- WASHINGTON UNIVERSITY — SAINT LOUIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SCHNEIDER, AIDAN — WASHINGTON UNIVERSITY
- Study coordinator: SCHNEIDER, AIDAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease