Understanding how individual factors affect treatment in dogs with leishmaniasis.
Official title: Evaluating Treatment Efficacy in Canine Visceral Leishmaniasis: The Role of Individual Factors and Co-Infections in Disease Control and Therapeutic Response.
Funded at University of North Carolina Charlotte · NIH-11115397 · Data updated 2026-11-12
This study is looking at how well different treatments work for dogs with a disease called canine visceral leishmaniasis, and it wants to find out how things like the dog's health and other infections might affect their recovery, so we can help more dogs get better.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of North Carolina Charlotte NIH-funded |
| Lab location | 1 site (Charlotte, United States) |
| Project start | April 24, 2025 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $77,000 |
| NIH project number | 1R03AI190139-01 |
| Project ID | NIH-11115397 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are dogs diagnosed with visceral leishmaniasis, particularly those receiving or having received treatment.
✕Less likely to help
Dogs that are not diagnosed with visceral leishmaniasis or those that have not undergone treatment may not benefit from this research.
What this research studies
This research investigates the effectiveness of treatments for canine visceral leishmaniasis (CVL), a disease caused by a parasite that affects dogs and can pose risks to humans. The study focuses on how individual characteristics of dogs and the presence of co-infections may influence their response to treatment with miltefosine, allopurinol, and domperidone. By analyzing treatment outcomes, the research aims to identify factors that lead to therapeutic failures and successes, ultimately improving treatment strategies for affected dogs.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatment protocols for dogs suffering from leishmaniasis, reducing the risk of transmission to humans.
How similar studies have gone: Previous research has shown varying success in treating canine visceral leishmaniasis, but this study aims to explore novel factors influencing treatment outcomes.
Where this research is happening
-
University of North Carolina Charlotte
Charlotte, United States Active
Researchers
- Principal investigator: Da Costa Vieira, Rafael Felipe — University of North Carolina Charlotte
- Study coordinator: Da Costa Vieira, Rafael Felipe
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.