Understanding how individual differences affect drug metabolism
Chemical biology approaches to understand interindividual variability in carboxylesterase activity
['FUNDING_R15'] · EASTERN ILLINOIS UNIVERSITY · NIH-10793059
This study is looking at how differences in certain enzymes that help break down medications can change how people respond to the same drug, with the hope of making treatments more personalized and effective for everyone.
Quick facts
| Phase | ['FUNDING_R15'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | EASTERN ILLINOIS UNIVERSITY (nih funded) |
| Locations | 1 site (CHARLESTON, UNITED STATES) |
| Trial ID | NIH-10793059 on ClinicalTrials.gov |
What this research studies
This research investigates how variations in the activity of carboxylesterases, enzymes crucial for drug metabolism, can affect how different people process medications. By developing specialized probes, the study aims to measure these enzyme activities in live samples, providing insights into why some patients may respond differently to the same drug. The goal is to enhance our understanding of drug bioavailability and improve personalized medicine approaches for better treatment outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who are prescribed medications that are metabolized by carboxylesterases, particularly those with varying responses to these drugs.
Not a fit: Patients who are not taking medications metabolized by carboxylesterases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more personalized drug therapies that are tailored to individual metabolic profiles, improving treatment efficacy and safety.
How similar studies have performed: Previous research has shown promise in understanding drug metabolism through enzyme activity studies, indicating that this approach could yield valuable insights.
Where this research is happening
CHARLESTON, UNITED STATES
- EASTERN ILLINOIS UNIVERSITY — CHARLESTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BECK, MICHAEL WILLIAM — EASTERN ILLINOIS UNIVERSITY
- Study coordinator: BECK, MICHAEL WILLIAM
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.