Understanding how individual differences affect drug metabolism
Official title: Chemical biology approaches to understand interindividual variability in carboxylesterase activity
Funded at Eastern Illinois University · NIH-10793059 · Data updated 2026-11-12
This study is looking at how differences in certain enzymes that help break down medications can change how people respond to the same drug, with the hope of making treatments more personalized and effective for everyone.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Eastern Illinois University NIH-funded |
| Lab location | 1 site (Charleston, United States) |
| Project start | February 1, 2024 |
| Project end | January 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $355,211 |
| NIH project number | 1R15GM152890-01 |
| Project ID | NIH-10793059 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals who are prescribed medications that are metabolized by carboxylesterases, particularly those with varying responses to these drugs.
✕Less likely to help
Patients who are not taking medications metabolized by carboxylesterases may not benefit from this research.
What this research studies
This research investigates how variations in the activity of carboxylesterases, enzymes crucial for drug metabolism, can affect how different people process medications. By developing specialized probes, the study aims to measure these enzyme activities in live samples, providing insights into why some patients may respond differently to the same drug. The goal is to enhance our understanding of drug bioavailability and improve personalized medicine approaches for better treatment outcomes.
Why it matters
Potential benefit: If successful, this research could lead to more personalized drug therapies that are tailored to individual metabolic profiles, improving treatment efficacy and safety.
How similar studies have gone: Previous research has shown promise in understanding drug metabolism through enzyme activity studies, indicating that this approach could yield valuable insights.
Where this research is happening
-
Eastern Illinois University
Charleston, United States Active
Researchers
- Principal investigator: Beck, Michael William — Eastern Illinois University
- Study coordinator: Beck, Michael William
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.