Understanding how individual cells regulate their biological clocks
Resolving the spatial dynamics of single cell circadian regulatory networks
This study is looking at how individual plant cells, like those in Arabidopsis thaliana, keep track of time throughout the day and night, which helps them respond to changes in their environment, and it could help us understand how these rhythms impact plant health and growth.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-10894744 on NIH RePORTER |
What this research studies
This research investigates the intricate mechanisms by which individual cells in plants, specifically Arabidopsis thaliana, manage their circadian rhythms. By utilizing advanced single-cell technologies, the study aims to identify distinct cell types and their unique regulatory networks that govern these biological clocks. This approach allows for a deeper understanding of how cellular processes align with environmental changes, which is crucial for overall physiological health. The findings could lead to new insights into how circadian rhythms affect various biological functions and disorders.
Who could benefit from this research
Good fit: Ideal candidates for benefiting from this research include individuals with cardiometabolic disorders or degenerative neurological conditions that may be influenced by circadian misalignment.
Not a fit: Patients who do not have conditions related to circadian rhythms or metabolic health may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of circadian rhythms, potentially leading to improved treatments for conditions related to metabolic and neurological health.
How similar studies have performed: While the specific approach of using single-cell technologies in this context is relatively novel, previous research has shown success in understanding circadian rhythms through model organisms.
Where this research is happening
Minneapolis, United States
- University of Minnesota — Minneapolis, United States (Active)
Researchers
- Principal investigator: Greenham, Kathleen M — University of Minnesota
- Study coordinator: Greenham, Kathleen M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.