Understanding how individual cells in the body differ from each other
Official title: Scalable single-cell workflow for multiomic analyses of chromatin interactions, accessibility, gene expression and cell surface proteins to unravel mechanisms of cellular diversity
Funded at Arima Genomics, INC. · NIH-10786071 · Data updated 2026-11-12
This study is looking at how different types of cells work by examining their DNA and proteins, which could help us understand why cells behave differently and how mistakes in these processes might lead to diseases, ultimately helping to improve diagnosis and treatment options for patients.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Arima Genomics, INC. NIH-funded |
| Lab location | 1 site (San Diego, United States) |
| Project start | February 15, 2023 |
| Project end | January 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $1,084,321 |
| NIH project number | 5R44GM149103-02 |
| Project ID | NIH-10786071 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with conditions related to gene expression mis-regulation, such as certain cancers or genetic disorders.
✕Less likely to help
Patients with stable conditions that do not involve gene expression issues may not benefit from this research.
What this research studies
This research investigates the unique characteristics of individual cells by analyzing their chromatin interactions, gene expression, and surface proteins. Using advanced techniques like single-cell ATAC sequencing and single-cell RNA sequencing, the study aims to map the regulatory elements that control gene expression in various cell types. By understanding these mechanisms, researchers hope to uncover the reasons behind cellular diversity and how mis-regulation can lead to diseases. This knowledge could pave the way for improved diagnostic and therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to better diagnostic tools and targeted therapies for diseases caused by gene mis-regulation.
How similar studies have gone: Previous research has shown promise in using single-cell sequencing techniques to understand cellular diversity, indicating that this approach has potential for success.
Where this research is happening
-
Arima Genomics, INC.
San Diego, United States Active
Researchers
- Principal investigator: Schmitt, Anthony — Arima Genomics, INC.
- Study coordinator: Schmitt, Anthony
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.