Understanding how individual cancer cells develop in blood cancers.
Official title: Tracing the lineage histories and differentiation trajectories of individual cancer cells in myeloproliferative neoplasms
Funded at Dana-Farber Cancer Inst · NIH-11009051 · Data updated 2026-11-12
This study is looking at how certain changes in cancer cells can affect how myeloproliferative neoplasms (MPNs) show up in different patients, with the goal of finding better, personalized treatments based on the unique behavior of each person's cancer cells.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dana-Farber Cancer Inst NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | January 15, 2021 |
| Project end | January 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $442,500 |
| NIH project number | 5R01HL158269-05 |
| Project ID | NIH-11009051 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with myeloproliferative neoplasms who are experiencing varying disease symptoms.
✕Less likely to help
Patients with other types of blood cancers or those who do not have myeloproliferative neoplasms may not benefit from this research.
What this research studies
This research investigates how specific mutations in cancer cells lead to different disease outcomes in patients with myeloproliferative neoplasms (MPNs). By tracing the lineage and differentiation of individual cancer cells, the study aims to identify when and where mutations occur in hematopoietic stem cells. The approach involves profiling each cell to understand the differences between cancerous and healthy cells, which may help explain the variability in disease presentation among patients. This could lead to more personalized treatment strategies based on individual cell behavior.
Why it matters
Potential benefit: If successful, this research could lead to more tailored and effective treatments for patients with blood cancers.
How similar studies have gone: Other research has shown promise in understanding cancer cell behavior through lineage tracing, indicating potential for success in this approach.
Where this research is happening
-
Dana-Farber Cancer Inst
Boston, United States Active
Researchers
- Principal investigator: Hormoz, Sahand — Dana-Farber Cancer Inst
- Study coordinator: Hormoz, Sahand
Related research
Other NIH-funded projects on the same topics.
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Myeloproliferative Neoplasm Research Consortium
A large research collaboration across multiple centers aims to improve survival for patients with myelofibrosis and related myeloproliferative neoplasms through coordinated laboratory, translational, and clinical work.
-
Understanding how different CALR mutations drive certain blood cancers
This grant explores how two CALR mutation types cause myeloproliferative neoplasms and could lead to better treatments for people with these blood cancers.
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Cell Competition in Myeloproliferative Neoplasms
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-
Targeting ERK’s brake pedals to slow cancer progression
Aims to block the parts of ERK signaling that speed up cancer progression, by guiding drugs to the substrate-binding domains that act like accelerator pedals in myeloproliferative neoplasms and related cancers.
-
Biomarker work to predict pancreatic IPMN cancer risk
A Duke University researcher is testing biomarkers to tell which pancreatic IPMN cysts are likely to become invasive cancer.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.