Understanding how individual bacteria contribute to bacterial vaginosis
Official title: Defining the role of single-cell heterogeneity in bacterial vaginosis
Funded at Case Western Reserve University · NIH-10949402 · Data updated 2026-11-12
This study is looking at how different types of bacteria in the vagina work together and affect the common condition called bacterial vaginosis (BV), with the goal of finding better ways to prevent and treat it for women who experience this issue.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | August 15, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $483,000 |
| NIH project number | 1DP2AI184733-01 |
| Project ID | NIH-10949402 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are reproductive-aged women who experience symptoms of bacterial vaginosis or have a history of recurrent BV.
✕Less likely to help
Patients who do not have bacterial vaginosis or are not of reproductive age may not benefit from this research.
What this research studies
This research investigates the complex interactions of bacteria that lead to bacterial vaginosis (BV), a common condition affecting many women. By examining the genetic and functional diversity of individual bacteria within the vaginal microbiome, the study aims to uncover the factors that influence the onset and recurrence of BV. The approach includes advanced genomic and transcriptomic analyses to better understand how these microbial communities behave and respond to treatments. This could lead to more effective prevention and treatment strategies for BV.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and prevention strategies for bacterial vaginosis, reducing its recurrence and associated health risks.
How similar studies have gone: Previous research has shown promise in understanding microbial communities, but this specific focus on single-cell diversity in BV is relatively novel.
Where this research is happening
-
Case Western Reserve University
Cleveland, United States Active
Researchers
- Principal investigator: Lewin, Gina — Case Western Reserve University
- Study coordinator: Lewin, Gina
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.