Understanding how incretin hormones affect insulin secretion in diabetes
Official title: Mechanisms Driving the Kinetics of Incretin-Mediated Beta Cell Responses
Funded at University of California at Davis · NIH-11034049 · Data updated 2026-11-12
This study is looking at how certain hormones in your body help your pancreas release insulin, which is important for managing Type 2 Diabetes, and it aims to find better ways to treat the condition by understanding how these hormones work.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $41,568 |
| NIH project number | 5F31DK136313-02 |
| Project ID | NIH-11034049 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Type 2 Diabetes Mellitus who are interested in new treatment options.
✕Less likely to help
Patients with Type 1 Diabetes or those without diabetes may not benefit from this research.
What this research studies
This research investigates the roles of incretin hormones, specifically GLP-1 and GIP, in stimulating insulin secretion from beta cells in individuals with Type 2 Diabetes Mellitus (T2DM). By examining how these hormones activate specific receptors and generate cAMP, a crucial signaling molecule, the study aims to uncover the differences in their effectiveness. The research employs advanced imaging techniques to visualize cAMP responses in beta cells, providing insights into the mechanisms that may lead to improved diabetes treatments. Ultimately, this work seeks to bridge knowledge gaps regarding incretin signaling and its impact on insulin secretion.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for Type 2 Diabetes Mellitus by enhancing our understanding of incretin hormone signaling.
How similar studies have gone: Previous research has shown promising results in understanding incretin signaling, but this specific comparison of GLP-1 and GIP signaling kinetics is novel.
Where this research is happening
-
University of California at Davis
Davis, United States Active
Researchers
- Principal investigator: Chan, Michelle Ying-Ying — University of California at Davis
- Study coordinator: Chan, Michelle Ying-Ying
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.