Understanding how increased fat tissue affects heart failure with preserved ejection fraction.
Mechanistic underpinnings of increased adipose tissue in HFpEF
This study is looking at how extra body fat might affect heart function in people with heart failure that still pumps well, to help find new ways to treat this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University Medical Campus NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10444973 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind heart failure with preserved ejection fraction (HFpEF), particularly focusing on the role of increased adipose tissue. It aims to understand how obesity and fat tissue contribute to the development and progression of HFpEF, which affects a significant number of patients. By exploring the relationship between adiposity, inflammation, and heart function, the study seeks to identify potential therapeutic targets. Patients may be involved in assessments that help clarify these mechanisms and their implications for treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who are diagnosed with heart failure with preserved ejection fraction, particularly those who are overweight or obese.
Not a fit: Patients with heart failure not classified as preserved ejection fraction or those without obesity may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new, targeted therapies for patients suffering from heart failure with preserved ejection fraction.
How similar studies have performed: Previous research has shown promising results in understanding the role of adipose tissue in heart failure, indicating that this approach may lead to significant advancements in treatment.
Where this research is happening
Boston, United States
- Boston University Medical Campus — Boston, United States (Active)
Researchers
- Principal investigator: Sam, Flora — Boston University Medical Campus
- Study coordinator: Sam, Flora
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.