Understanding how increased brain activity affects ALS
Official title: Mechanistic insights of cortical hyperexcitability in ALS
Funded at Emory University · NIH-10986723 · Data updated 2026-11-12
This study is looking at how overactive brain cells might contribute to ALS, focusing on early signs like muscle twitching and cramps, to help find new ways to treat the disease sooner.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $75,699 |
| NIH project number | 3R21NS133960-01S1 |
| Project ID | NIH-10986723 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with ALS or those experiencing early symptoms such as muscle twitching or cramps.
✕Less likely to help
Patients with advanced ALS who have significant motor neuron loss may not benefit from this research.
What this research studies
This research investigates the role of hyperexcitability in the motor cortex as a potential driver of amyotrophic lateral sclerosis (ALS). By using advanced techniques to target specific cells in the brain, the study aims to uncover the mechanisms that lead to the degeneration of motor neurons. The researchers will analyze how early signs of increased neural activity, such as muscle twitching and cramps, relate to the progression of ALS. This could provide insights into new therapeutic strategies that could be implemented early in the disease.
Why it matters
Potential benefit: If successful, this research could lead to earlier interventions that slow or prevent the progression of ALS.
How similar studies have gone: Previous research has shown promising results in understanding motor neuron diseases through similar approaches, indicating potential for success in this area.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Jiang, Jie — Emory University
- Study coordinator: Jiang, Jie
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.