Understanding how incomplete DNA replication leads to genetic changes
Official title: Cell cycle timing and molecular mechanisms of structural variant formation following incomplete replication
Funded at University of Michigan at Ann Arbor · NIH-11052493 · Data updated 2026-11-12
This study is looking at how mistakes in DNA copying can lead to cancer and genetic diseases, and it's for anyone interested in understanding how our cells fix these mistakes and what happens when they don't.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | April 12, 2023 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $494,161 |
| NIH project number | 5R01GM147026-03 |
| Project ID | NIH-11052493 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a family history of genetic diseases or cancers related to DNA replication errors.
✕Less likely to help
Patients with conditions unrelated to DNA replication or structural variants may not benefit from this research.
What this research studies
This research investigates the mechanisms behind genetic mutations that occur when DNA replication is incomplete, which can lead to cancer and genetic diseases. By studying how structural variants, particularly copy number variants, form during this process, the research aims to fill gaps in our understanding of DNA repair mechanisms. The approach involves using human cell models to observe the effects of incomplete replication and the resulting genetic changes. This could provide insights into the timing and molecular processes involved in these mutations.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potential treatments for cancers and genetic diseases caused by DNA replication errors.
How similar studies have gone: Previous research has shown promising results in understanding DNA repair mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Wilson, Thomas Edward — University of Michigan at Ann Arbor
- Study coordinator: Wilson, Thomas Edward
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.