Understanding how importins regulate the NLRP6 inflammasome
Official title: Elucidating the novel mechanism of importins in NLRP6 inflammasome regulation
Funded at Washington University · NIH-10904635 · Data updated 2026-11-12
This study is looking at how certain proteins help control an important part of the immune system that can cause inflammation, with the hope of finding better treatments for chronic conditions like inflammatory bowel disease.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | August 10, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $194,375 |
| NIH project number | 5R21AI173896-02 |
| Project ID | NIH-10904635 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals suffering from chronic inflammatory conditions, particularly inflammatory bowel disease.
✕Less likely to help
Patients with acute infections or those not suffering from chronic inflammatory diseases may not receive direct benefits from this research.
What this research studies
This research investigates the role of importins in regulating the NLRP6 inflammasome, which is crucial for the body's immune response. By examining how these proteins influence the activation of caspase-1 and the subsequent release of inflammatory cytokines, the study aims to uncover mechanisms that could lead to better treatments for chronic inflammatory diseases. The research involves biochemical assays and cellular models to explore the signaling pathways involved in inflammasome regulation. Patients may benefit from insights gained that could lead to targeted therapies for conditions like inflammatory bowel disease.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for chronic inflammatory diseases by better understanding inflammasome regulation.
How similar studies have gone: Previous research has shown success in understanding inflammasome mechanisms, indicating that this approach has potential for meaningful advancements.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Shen, Chen — Washington University
- Study coordinator: Shen, Chen
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.