Understanding how important channels in our cells are controlled
Dynamic modulation of HCN4 and ASICs
This research looks at how tiny channels in our cells, called ion channels, are controlled, especially those linked to pain, stroke, and heart function.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-11090078 on NIH RePORTER |
What this research studies
Ion channels are like tiny gates in our cells that control how signals pass through, sensing things like pH, temperature, and electrical changes. This project focuses on two specific types: ASICs, which sense acidity and are involved in pain and brain damage after a stroke, and HCN channels, which are key for how our nerve cells and heart pacemaker cells work. We want to learn more about how these channels are regulated by factors like the cell membrane and other proteins. By understanding these mechanisms, we hope to find new ways to target these channels with medicines, potentially leading to better treatments for conditions like stroke, pain, and heart rhythm problems.
Who could benefit from this research
Good fit: Patients who might eventually benefit from this research are those living with chronic pain, recovering from stroke, or experiencing certain heart rhythm disorders.
Not a fit: Patients without conditions related to ion channel dysfunction in the nervous system or heart may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this research could lead to new drug targets and improved treatments for conditions such as stroke, chronic pain, and certain heart conditions.
How similar studies have performed: While the specific mechanisms of dynamic modulation are still being uncovered, ion channels are well-established drug targets, and other research has shown their importance in these conditions.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Bankston, John — University of Colorado Denver
- Study coordinator: Bankston, John
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.