Understanding how immunotherapy works in pancreatic cancer
Mechanisms of immunotherapy response and resistance in pancreatic ductal adenocarcinoma
This study is looking at why some people with pancreatic cancer benefit from immunotherapy while others don’t, and it aims to find better treatment combinations that can help boost the immune system's fight against this tough cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-11035117 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind why some patients with pancreatic ductal adenocarcinoma respond to immunotherapy while others do not. By creating novel animal models, the team aims to study the behavior of specific immune cells that target pancreatic cancer over time. The goal is to identify effective combinations of therapies that can enhance the immune response against this aggressive cancer. Ultimately, the findings will inform the development of new treatment strategies that could be tested in clinical trials.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with pancreatic ductal adenocarcinoma who are seeking new treatment options.
Not a fit: Patients with early-stage pancreatic cancer or those who do not have pancreatic ductal adenocarcinoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective immunotherapy options for patients with pancreatic cancer.
How similar studies have performed: Other research has shown promising results with immunotherapy in different cancers, but this specific approach in pancreatic cancer is relatively novel.
Where this research is happening
Minneapolis, United States
- University of Minnesota — Minneapolis, United States (Active)
Researchers
- Principal investigator: Stromnes, Ingunn Margarete — University of Minnesota
- Study coordinator: Stromnes, Ingunn Margarete
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.