Understanding how immunotherapy affects tumors and their environment in patients
Dynamic Analysis of Tumor and Microenvironment in Patients Undergoing Immunotherapy
This study is looking at how immunotherapy affects the area around tumors in people with follicular lymphoma, hoping to learn why some patients do better with this treatment than others by examining their tumor samples over time.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project ID | NIH-10911931 on NIH RePORTER |
What this research studies
This research investigates how immunotherapy influences the tumor microenvironment (TME) in patients with follicular lymphoma. By analyzing tumor samples collected over time from patients undergoing in situ vaccination, the study aims to uncover the immune system's interactions with cancer cells. Utilizing advanced techniques in single-cell genomics and bioinformatics, researchers will explore changes in T-cell characteristics and tumor responses to treatment. This approach seeks to improve our understanding of why some patients respond to immunotherapy while others do not.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with follicular lymphoma who are undergoing immunotherapy.
Not a fit: Patients with other types of cancer or those not receiving immunotherapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective immunotherapy treatments tailored to individual patient responses.
How similar studies have performed: Previous research has shown promising results in understanding tumor-immune interactions, but this specific approach is relatively novel.
Where this research is happening
Portland, United States
- Oregon Health & Science University — Portland, United States (Active)
Researchers
- Principal investigator: Shree, Tanaya — Oregon Health & Science University
- Study coordinator: Shree, Tanaya
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.