Understanding how immunity to SARS-CoV-2 works in older adults

Mechanisms and Duration of Immunity to SARS-CoV-2

['FUNDING_OTHER'] · STANFORD UNIVERSITY · NIH-10688360

This study is looking at how older adults' immune systems respond to the COVID-19 virus, whether they've been infected or vaccinated, to find out what helps them build strong and lasting protection against the virus.

Quick facts

Phase['FUNDING_OTHER']
Study typeNih_funding
SexAll
SponsorSTANFORD UNIVERSITY (nih funded)
Locations1 site (STANFORD, UNITED STATES)
Trial IDNIH-10688360 on ClinicalTrials.gov

What this research studies

This research investigates the immune responses of older adults to the SARS-CoV-2 virus, focusing on how their bodies produce antibodies and other immune cells after infection or vaccination. The study aims to analyze blood samples and mucosal responses to identify factors that contribute to long-lasting immunity. By comparing responses from those who have recovered from COVID-19 and those who have been vaccinated, the research seeks to uncover insights that could help improve treatments and preventive measures for this vulnerable population.

Who could benefit from this research

Good fit: Ideal candidates for this research are older adults, particularly those who are medically underserved or at higher risk for severe COVID-19 outcomes.

Not a fit: Patients who are younger and not at risk for severe COVID-19 may not receive direct benefits from this research.

Why it matters

Potential benefit: If successful, this research could lead to better understanding and improved strategies for protecting older adults against COVID-19.

How similar studies have performed: Previous research has shown promising results in understanding immune responses to other viruses, suggesting that this approach could yield valuable insights.

Where this research is happening

STANFORD, UNITED STATES

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.

View on NIH RePORTER →

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.