Understanding how immune system issues affect wound healing in a rare childhood disease.
Crosstalk of Immune Dysregulation and Impaired Wound Healing in inherited STAT4-mediated Autoinflammatory Disease
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA, SAN DIEGO · NIH-11105513
This study is looking at how a specific change in a gene might be causing ongoing inflammation and slow healing in people with a condition called disabling pansclerotic morphea, with the goal of finding new ways to help improve healing and overall health for patients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN DIEGO (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-11105513 on ClinicalTrials.gov |
What this research studies
This research investigates the role of a specific genetic mutation in the STAT4 gene that causes immune dysregulation and impaired wound healing in patients with disabling pansclerotic morphea (DPM). The study aims to understand how this mutation leads to persistent inflammation and affects the development and activation of immune cells. By exploring the mechanisms involved, the researchers hope to identify potential therapeutic targets that could improve wound healing and overall patient outcomes. The approach includes both laboratory experiments and clinical observations to validate findings.
Who could benefit from this research
Good fit: Ideal candidates for this research are children diagnosed with disabling pansclerotic morphea who exhibit symptoms of immune dysregulation.
Not a fit: Patients with other forms of skin disorders or those without the specific STAT4 mutation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve wound healing and quality of life for patients with DPM.
How similar studies have performed: Previous research has shown promising results in targeting immune dysregulation in similar autoinflammatory diseases, suggesting potential for success in this approach.
Where this research is happening
LA JOLLA, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN DIEGO — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BRODERICK, LORI — UNIVERSITY OF CALIFORNIA, SAN DIEGO
- Study coordinator: BRODERICK, LORI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.