Understanding how immune system issues affect wound healing in a rare childhood disease.
Official title: Crosstalk of Immune Dysregulation and Impaired Wound Healing in inherited STAT4-mediated Autoinflammatory Disease
Funded at University of California, San Diego · NIH-11105513 · Data updated 2026-11-12
This study is looking at how a specific change in a gene might be causing ongoing inflammation and slow healing in people with a condition called disabling pansclerotic morphea, with the goal of finding new ways to help improve healing and overall health for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | February 1, 2025 |
| Project end | January 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $385,575 |
| NIH project number | 1R01AI189984-01 |
| Project ID | NIH-11105513 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children diagnosed with disabling pansclerotic morphea who exhibit symptoms of immune dysregulation.
✕Less likely to help
Patients with other forms of skin disorders or those without the specific STAT4 mutation may not benefit from this research.
What this research studies
This research investigates the role of a specific genetic mutation in the STAT4 gene that causes immune dysregulation and impaired wound healing in patients with disabling pansclerotic morphea (DPM). The study aims to understand how this mutation leads to persistent inflammation and affects the development and activation of immune cells. By exploring the mechanisms involved, the researchers hope to identify potential therapeutic targets that could improve wound healing and overall patient outcomes. The approach includes both laboratory experiments and clinical observations to validate findings.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve wound healing and quality of life for patients with DPM.
How similar studies have gone: Previous research has shown promising results in targeting immune dysregulation in similar autoinflammatory diseases, suggesting potential for success in this approach.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Broderick, Lori — University of California, San Diego
- Study coordinator: Broderick, Lori
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.