Understanding How Immune Signals Affect Metabolism in Obesity
Metabolic Impacts of Type II Interferon Signals in Obesity
['FUNDING_R01'] · BAYLOR COLLEGE OF MEDICINE · NIH-11123327
This work explores how immune system signals in fat tissue contribute to obesity and the development of type 2 diabetes.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BAYLOR COLLEGE OF MEDICINE (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-11123327 on ClinicalTrials.gov |
What this research studies
We know that obesity often comes with inflammation in fat tissues and insulin resistance, which can lead to type 2 diabetes. Our previous work showed that blocking a specific immune signal, interferon gamma (IFNγ), could help prevent some negative effects of a high-fat diet, like weight gain and insulin resistance. This project aims to discover exactly how IFNγ signals in fat cells affect metabolism and insulin sensitivity. We want to understand the fundamental ways these signals change how fat cells use energy.
Who could benefit from this research
Good fit: This foundational research is relevant to individuals living with obesity, insulin resistance, or type 2 diabetes.
Not a fit: Patients not affected by obesity, insulin resistance, or type 2 diabetes would likely not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to prevent or treat insulin resistance and type 2 diabetes by targeting specific immune pathways in fat tissue.
How similar studies have performed: Previous work by this team and others has shown promising links between inflammation and insulin resistance, suggesting this approach builds on existing knowledge.
Where this research is happening
HOUSTON, UNITED STATES
- BAYLOR COLLEGE OF MEDICINE — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HARTIG, SEAN — BAYLOR COLLEGE OF MEDICINE
- Study coordinator: HARTIG, SEAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Adult-Onset Diabetes Mellitus