Understanding how immune sensors affect colorectal cancer development
Innate immune sensors, inflammasomes, and inflammasome-mediated processes in cancer
This study is looking at how certain parts of our immune system might help colorectal cancer grow, with the hope of finding new treatments that could help patients like you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Jude Children's Research Hospital NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project ID | NIH-10896912 on NIH RePORTER |
What this research studies
This research investigates the role of innate immune sensors and inflammasomes in the development of colorectal cancer, particularly focusing on how these immune pathways contribute to tumor progression. By studying the mechanisms of these immune responses, the research aims to identify potential drug targets that could lead to new treatments for colorectal cancer. The approach involves basic science techniques to unravel the interactions between immune signaling and cell death regulators, which are crucial for understanding disease development. Patients may benefit from advancements in therapeutic strategies derived from this research.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for or diagnosed with colorectal cancer, particularly those with colitis-associated forms of the disease.
Not a fit: Patients with cancers unrelated to colorectal cancer or those not affected by immune system dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic options for colorectal cancer patients.
How similar studies have performed: Previous research has shown promise in understanding immune responses in cancer, indicating that this approach could lead to significant advancements in treatment.
Where this research is happening
Memphis, United States
- St. Jude Children's Research Hospital — Memphis, United States (Active)
Researchers
- Principal investigator: Kanneganti, Thirumala-Devi — St. Jude Children's Research Hospital
- Study coordinator: Kanneganti, Thirumala-Devi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.