Understanding how immune responses in monocytes affect brain degeneration
nbInnate Immunity Responses In Monocytes: Contribution To Neurodegeneration
This study is looking at how certain immune cells called monocytes affect brain health in people with Alzheimer's disease and HIV-related cognitive issues, hoping to find new ways to help treat these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Puerto Rico Med Sciences NIH-funded |
| Lab location | 1 site (San Juan, United States) |
| Project ID | NIH-10931707 on NIH RePORTER |
What this research studies
This research investigates the role of innate immune responses in monocytes and their contribution to neurodegeneration, particularly in Alzheimer's disease and HIV-associated neurocognitive disorders. The study focuses on how monocytes, which are immune cells, interact with the brain and influence the accumulation of beta-amyloid plaques, a hallmark of Alzheimer's disease. By examining the signaling pathways involved, particularly the interferon type I response, the research aims to uncover mechanisms that could lead to new therapeutic strategies for these conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Alzheimer's disease or those living with HIV who are experiencing cognitive decline.
Not a fit: Patients with other forms of dementia unrelated to Alzheimer's or HIV may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients suffering from Alzheimer's disease and HIV-related cognitive disorders.
How similar studies have performed: Previous research has shown promising results in understanding the immune response in neurodegeneration, suggesting that this approach could yield valuable insights.
Where this research is happening
San Juan, United States
- University of Puerto Rico Med Sciences — San Juan, United States (Active)
Researchers
- Principal investigator: Cantres-Rosario, Yisel M. — University of Puerto Rico Med Sciences
- Study coordinator: Cantres-Rosario, Yisel M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.