Understanding how immune responses develop and persist in the body
Official title: Core A: Administrative Core
Funded at University of Alabama at Birmingham · NIH-11075841 · Data updated 2026-11-12
This study is looking at how your immune system, especially certain cells called B and T cells, changes and remembers things over time after infections or vaccines, to help us understand how to make better treatments for diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project start | April 16, 2024 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $434,363 |
| NIH project number | 5U19AI181105-02 |
| Project ID | NIH-11075841 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with autoimmune conditions or those undergoing vaccination who are interested in understanding their immune response.
✕Less likely to help
Patients who do not have an adaptive immune response or are not undergoing any immune-modulating treatments may not benefit from this research.
What this research studies
This research investigates the development and longevity of human adaptive immune responses, particularly focusing on B and T cells. It aims to analyze how these immune cells evolve over time in response to infections, vaccines, and immune-modulating treatments. By studying immune cells not just in the blood but also in tissues, the research seeks to uncover the complexities of immune memory and its role in protection against diseases. This approach may provide insights into how to better harness the immune system for therapeutic purposes.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for enhancing immune responses in patients, potentially benefiting those with autoimmune diseases or those requiring vaccinations.
How similar studies have gone: Previous studies have shown success in understanding immune responses through similar methodologies, particularly in animal models, but this research aims to apply those insights to human subjects.
Where this research is happening
-
University of Alabama at Birmingham
Birmingham, United States Active
Researchers
- Principal investigator: Lund, Frances E. — University of Alabama at Birmingham
- Study coordinator: Lund, Frances E.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.