Understanding how immune responses can help treat resistant prostate cancer
Leveraging PMN immune response to overcome ADT resistance in bone metastatic prostate cancer
This study is looking at how certain immune cells in the blood of men with advanced prostate cancer respond to the disease, especially in the bones, to understand how their function changes over time and how treatment affects them, with the goal of finding better ways to fight the cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Medical Center NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project ID | NIH-10897051 on NIH RePORTER |
What this research studies
This research investigates the immune response of polymorphonuclear leukocytes (PMNs) in patients with metastatic castration-resistant prostate cancer (mCRPC), particularly focusing on how these immune cells interact with the cancer in the bone environment. The study aims to identify the changes in PMN function as the disease progresses and how androgen deprivation therapy (ADT) affects these immune responses. By analyzing blood samples from patients at various stages of prostate cancer, the research seeks to uncover mechanisms of resistance to treatment and develop new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include men diagnosed with metastatic castration-resistant prostate cancer, particularly those who have undergone androgen deprivation therapy.
Not a fit: Patients with localized prostate cancer or those who have not received androgen deprivation therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for patients with advanced prostate cancer who currently have limited effective therapies.
How similar studies have performed: Previous research has shown promising results in understanding immune responses in cancer treatment, suggesting that this approach may yield valuable insights.
Where this research is happening
Omaha, United States
- University of Nebraska Medical Center — Omaha, United States (Active)
Researchers
- Principal investigator: Mathew, Grinu — University of Nebraska Medical Center
- Study coordinator: Mathew, Grinu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.