Understanding how immune responses and DNA damage occur at micronuclei in cancer cells
Immune control and genomic instability at micronuclei
['FUNDING_R37'] · SLOAN-KETTERING INST CAN RESEARCH · NIH-10996156
This study is looking at tiny structures called micronuclei that can form when cancer cells divide incorrectly, and how they might cause DNA damage and trigger the immune system, which could affect how cancer grows; it's for anyone interested in learning more about how these processes work and what they might mean for cancer treatment.
Quick facts
| Phase | ['FUNDING_R37'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SLOAN-KETTERING INST CAN RESEARCH (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10996156 on ClinicalTrials.gov |
What this research studies
This research investigates the role of micronuclei, which are small nuclear structures that can form during cell division errors in cancer cells. It focuses on how these micronuclei can lead to DNA damage and activate immune responses, potentially influencing cancer progression. The study examines the mechanisms behind these processes, particularly the involvement of a specific enzyme called TREX1, which is linked to immune diseases. By understanding these interactions, the research aims to uncover new insights into cancer biology and treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients with various types of cancer, particularly those exhibiting chromosomal instability.
Not a fit: Patients with stable cancer genomes or those not exhibiting chromosomal instability may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing anti-tumor immunity and improving cancer treatments.
How similar studies have performed: Other research has shown promising results in understanding immune responses related to DNA damage in cancer, suggesting that this approach has potential for significant findings.
Where this research is happening
NEW YORK, UNITED STATES
- SLOAN-KETTERING INST CAN RESEARCH — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MACIEJOWSKI, JOHN — SLOAN-KETTERING INST CAN RESEARCH
- Study coordinator: MACIEJOWSKI, JOHN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Aicardi Goutieres syndrome