Understanding how immune responses affect treatment outcomes in lung cancer
Immunogenomic determinants of response and resistance to neoadjuvant anti-PD-1 in resectable NSCLC
This study is looking at how the immune system reacts to a cancer treatment called anti-PD-1 therapy in patients with a type of lung cancer that can be surgically removed, to help find better ways to tailor treatments for each person based on their immune response.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11039926 on NIH RePORTER |
What this research studies
This research investigates the immune system's response to a specific cancer treatment called anti-PD-1 therapy in patients with resectable non-small cell lung cancer (NSCLC). By analyzing blood samples and tumor tissues from previous clinical trials, the study aims to uncover how different types of immune cells, particularly T cells, respond to this therapy. The researchers will use advanced sequencing techniques to track these immune cells and identify markers that predict treatment success or resistance. This could lead to more personalized treatment strategies for lung cancer patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with stage I or II resectable non-small cell lung cancer who are undergoing or have undergone anti-PD-1 therapy.
Not a fit: Patients with advanced or metastatic lung cancer, or those who are not candidates for surgery, may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies that enhance the effectiveness of anti-PD-1 therapy for lung cancer patients.
How similar studies have performed: Previous studies have shown promising results with similar approaches in understanding immune responses to cancer therapies, indicating potential for success in this research.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Smith, Kellie Nicole — Johns Hopkins University
- Study coordinator: Smith, Kellie Nicole
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.