Understanding how immune responses affect the blood-brain barrier in people with HIV
Immune dynamics shaping blood brain barrier integrity in virally suppressed people with HIV
This study is looking at how the immune system affects the protective barrier around the brain in people living with HIV who are on treatment, to see if certain immune cells might be linked to memory problems and feelings of sadness, and it’s open to those who want to help us understand these issues better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10897124 on NIH RePORTER |
What this research studies
This research investigates the relationship between immune system activity and the integrity of the blood-brain barrier in individuals living with HIV who are on effective antiretroviral therapy. The study aims to identify how certain immune cells and proteins may disrupt the blood-brain barrier, potentially leading to cognitive impairment and depression. Participants will undergo imaging and lumbar punctures to evaluate the condition of their blood-brain barrier, alongside assessments of their neuropsychiatric health. By comparing individuals with HIV to those without, the research seeks to uncover mechanisms that contribute to ongoing neurological issues in HIV-positive individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are virally suppressed and experiencing cognitive impairment or major depressive disorder.
Not a fit: Patients who are not living with HIV or those who are not virally suppressed may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for cognitive and mood disorders in people living with HIV.
How similar studies have performed: Previous research has indicated that immune system interactions with the central nervous system can impact neurological health, suggesting that this approach may yield valuable insights.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Rubin, Leah Helane — Johns Hopkins University
- Study coordinator: Rubin, Leah Helane
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.