Understanding how immune responses affect organ transplant success
Official title: Core C: Immuno-Reagent Production, Validation, and Biophysical Analysis Core
Funded at University of Alabama at Birmingham · NIH-11075851 · Data updated 2026-11-12
This study is looking at how the immune system reacts after an organ transplant, especially how certain cells can cause the body to reject the new organ, and it aims to find ways to help doctors better prevent this rejection so that transplant patients can have healthier, longer-lasting organs.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project start | April 16, 2024 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $434,363 |
| NIH project number | 5U19AI181105-02 |
| Project ID | NIH-11075851 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who are undergoing or have undergone organ transplantation, particularly kidney transplants.
✕Less likely to help
Patients who are not organ transplant recipients or those who do not have issues related to organ rejection may not benefit from this research.
What this research studies
This research investigates the immune responses that lead to organ rejection in transplant patients, particularly focusing on the role of antibody-secreting cells and memory B cells. It aims to identify the factors that influence the development of donor-specific antibodies after transplantation, which can significantly impact graft survival. By developing specific reagents to study these immune cells, the research seeks to improve our understanding of how to better manage and prevent organ rejection. Patients may benefit from insights that could lead to more effective immunosuppressive therapies.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing organ rejection, enhancing the longevity of transplanted organs.
How similar studies have gone: Previous research has shown promise in understanding immune responses in organ transplantation, but this specific approach to studying memory B cells and antibody-secreting cells is relatively novel.
Where this research is happening
-
University of Alabama at Birmingham
Birmingham, United States Active
Researchers
- Principal investigator: Green, Todd Jason — University of Alabama at Birmingham
- Study coordinator: Green, Todd Jason
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.