Understanding how immune responses affect organ transplant success
Core C: Immuno-Reagent Production, Validation, and Biophysical Analysis Core
This study is looking at how the immune system reacts after an organ transplant, especially how certain cells can cause the body to reject the new organ, and it aims to find ways to help doctors better prevent this rejection so that transplant patients can have healthier, longer-lasting organs.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project ID | NIH-11075851 on NIH RePORTER |
What this research studies
This research investigates the immune responses that lead to organ rejection in transplant patients, particularly focusing on the role of antibody-secreting cells and memory B cells. It aims to identify the factors that influence the development of donor-specific antibodies after transplantation, which can significantly impact graft survival. By developing specific reagents to study these immune cells, the research seeks to improve our understanding of how to better manage and prevent organ rejection. Patients may benefit from insights that could lead to more effective immunosuppressive therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are undergoing or have undergone organ transplantation, particularly kidney transplants.
Not a fit: Patients who are not organ transplant recipients or those who do not have issues related to organ rejection may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing organ rejection, enhancing the longevity of transplanted organs.
How similar studies have performed: Previous research has shown promise in understanding immune responses in organ transplantation, but this specific approach to studying memory B cells and antibody-secreting cells is relatively novel.
Where this research is happening
Birmingham, United States
- University of Alabama at Birmingham — Birmingham, United States (Active)
Researchers
- Principal investigator: Green, Todd Jason — University of Alabama at Birmingham
- Study coordinator: Green, Todd Jason
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.