Understanding how immune responses affect organ transplant success
The role of HLA and its coreceptors in endothelial cell activation and leukocyte recruitment in antibody-mediated transplant rejection
This study is looking at how certain immune proteins affect blood vessel cells and immune responses during organ transplant rejection, with the goal of finding better ways to prevent complications for transplant patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11054676 on NIH RePORTER |
What this research studies
This research investigates the role of specific immune proteins, known as HLA and its co-receptors, in the activation of blood vessel cells and the recruitment of immune cells during the rejection of transplanted organs. By studying how these proteins interact, the research aims to uncover mechanisms that lead to chronic rejection and vascular diseases in transplant patients. The approach includes examining cellular signaling pathways and immune responses in endothelial cells, which line blood vessels. This could lead to new strategies for preventing or treating complications in organ transplant recipients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have received solid organ transplants and exhibit donor-specific antibodies that may lead to rejection.
Not a fit: Patients who have not undergone organ transplantation or do not have donor-specific antibodies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could improve the outcomes of organ transplants by identifying new ways to prevent rejection and associated vascular diseases.
How similar studies have performed: Previous research has shown promising results in understanding immune responses in organ transplantation, suggesting that this approach could lead to significant advancements in the field.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Reed, Elaine F — University of California Los Angeles
- Study coordinator: Reed, Elaine F
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.