Understanding how immune responses affect lung transplant outcomes
Official title: Synergistic roles of lung autoantibodies, donor nonclassical monocytes and recipient classical monocytes in mediating primary graft dysfunction
Funded at Northwestern University at Chicago · NIH-10933923 · Data updated 2026-11-12
This study is looking at how certain immune responses, like specific antibodies and types of immune cells, might cause problems with lung function right after a lung transplant, and it's aimed at helping lung transplant patients by finding ways to prevent these issues.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | September 17, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $464,211 |
| NIH project number | 1P01HL169188-01A1 |
| Project ID | NIH-10933923 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals undergoing lung transplantation, particularly those with chronic lung diseases.
✕Less likely to help
Patients who are not candidates for lung transplantation or those without chronic lung conditions may not benefit from this research.
What this research studies
This research investigates the role of specific immune responses, particularly autoantibodies and different types of monocytes, in causing primary graft dysfunction (PGD) after lung transplantation. By studying lung transplant recipients, the research aims to identify how these immune factors contribute to lung injury in the critical early hours post-surgery. The approach includes using animal models to simulate lung transplantation and analyze the interactions between immune cells and antibodies that may worsen lung function. The goal is to uncover mechanisms that could lead to better management and prevention of PGD.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing lung injury in transplant patients, potentially reducing mortality and enhancing long-term transplant success.
How similar studies have gone: Previous research has shown that understanding immune responses in transplant settings can lead to significant advancements in patient outcomes, suggesting this approach has potential for success.
Where this research is happening
-
Northwestern University at Chicago
Chicago, United States Active
Researchers
- Principal investigator: Bharat, Ankit — Northwestern University at Chicago
- Study coordinator: Bharat, Ankit
Related research
Other NIH-funded projects on the same topics.
-
High-intensity exercise as a treatment for Parkinson's disease
This study is looking at whether doing high-intensity endurance exercise can help people who have just been diagnosed with Parkinson's disease feel better and slow down their symptoms, especially since current medications don't always do the trick.
-
Software to quickly assess organ dose after radionuclide exposure
This study is creating a helpful software tool that quickly calculates how much radiation your organs absorb after you've taken certain radioactive substances, so you can get better care and treatment based on your individual needs.
-
Investigating innovative approaches to improve health outcomes.
This study is looking for better ways to improve your care and treatment, so you can get more personalized options that work best for you.
-
Investigating innovative approaches to improve health outcomes.
This study is looking for new ways to improve care and treatment for patients, and if you join, you might help test some exciting new methods that could lead to better health for everyone.
-
Investigating innovative approaches to improve health outcomes.
This study is looking for ways to improve care and treatment for patients like you, by trying out new methods that could help manage your health better.
-
Investigating core biological processes
This study is all about exploring important biological processes that affect our health, and it invites patients to help discover new ways to improve care for everyone.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.