Understanding how immune responses affect lung transplant outcomes
Synergistic roles of lung autoantibodies, donor nonclassical monocytes and recipient classical monocytes in mediating primary graft dysfunction
This study is looking at how certain immune responses, like specific antibodies and types of immune cells, might cause problems with lung function right after a lung transplant, and it's aimed at helping lung transplant patients by finding ways to prevent these issues.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-10933923 on NIH RePORTER |
What this research studies
This research investigates the role of specific immune responses, particularly autoantibodies and different types of monocytes, in causing primary graft dysfunction (PGD) after lung transplantation. By studying lung transplant recipients, the research aims to identify how these immune factors contribute to lung injury in the critical early hours post-surgery. The approach includes using animal models to simulate lung transplantation and analyze the interactions between immune cells and antibodies that may worsen lung function. The goal is to uncover mechanisms that could lead to better management and prevention of PGD.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals undergoing lung transplantation, particularly those with chronic lung diseases.
Not a fit: Patients who are not candidates for lung transplantation or those without chronic lung conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing lung injury in transplant patients, potentially reducing mortality and enhancing long-term transplant success.
How similar studies have performed: Previous research has shown that understanding immune responses in transplant settings can lead to significant advancements in patient outcomes, suggesting this approach has potential for success.
Where this research is happening
Chicago, United States
- Northwestern University at Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Bharat, Ankit — Northwestern University at Chicago
- Study coordinator: Bharat, Ankit
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.