Understanding how immune responses affect gastric cancer development
Immune Regulation of Gastric Cancer
This study is looking at how certain hormones in our body can help reduce harmful inflammation caused by a stomach infection that might lead to cancer, and it's aimed at finding new ways to prevent gastric cancer for people at risk.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | West Virginia University NIH-funded |
| Lab location | 1 site (Morgantown, United States) |
| Project ID | NIH-10916369 on NIH RePORTER |
What this research studies
This research investigates the role of glucocorticoids, which are hormones produced by the adrenal glands, in regulating inflammation associated with Helicobacter pylori infection and its link to gastric cancer. The study aims to uncover the mechanisms by which these hormones can suppress harmful gastric inflammation that may lead to cancer. By using animal models, researchers will explore how the absence of glucocorticoid signaling affects gastric tissue and contributes to cancer progression. The findings could provide insights into new therapeutic strategies for preventing gastric cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of Helicobacter pylori infection or those at risk for gastric cancer.
Not a fit: Patients without Helicobacter pylori infection or those with advanced gastric cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent gastric cancer in patients with Helicobacter pylori infections.
How similar studies have performed: Previous research has shown that targeting inflammatory pathways can be effective in cancer prevention, suggesting potential success for this approach.
Where this research is happening
Morgantown, United States
- West Virginia University — Morgantown, United States (Active)
Researchers
- Principal investigator: Busada, Jonathan — West Virginia University
- Study coordinator: Busada, Jonathan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.