Understanding how immune responses affect eye inflammation in autoimmune uveitis
Regulation of the neuroinflammatory response in autoimmune uveitis
This study is looking at how certain immune cells in the eye might be causing problems in people with autoimmune uveitis, which can lead to vision loss, and it hopes to find new ways to help treat this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts Eye and Ear Infirmary NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10744201 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind autoimmune uveitis, a condition where the immune system mistakenly attacks the eye, leading to potential vision loss. The study focuses on the role of microglia, the immune cells in the retina, and how they contribute to the entry of harmful immune cells into the eye. By exploring the activation and function of these microglia, the research aims to uncover new insights into the disease process and identify potential therapeutic targets. Patients may benefit from a better understanding of their condition and new treatment options that could arise from this work.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with autoimmune uveitis or those experiencing unexplained vision problems related to immune responses.
Not a fit: Patients with non-autoimmune related eye conditions or those without any ocular symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for autoimmune uveitis, potentially preserving vision for affected patients.
How similar studies have performed: Previous research has shown promising results in understanding immune responses in other autoimmune conditions, suggesting that this approach may yield valuable insights.
Where this research is happening
Boston, United States
- Massachusetts Eye and Ear Infirmary — Boston, United States (Active)
Researchers
- Principal investigator: Ksander, Bruce R — Massachusetts Eye and Ear Infirmary
- Study coordinator: Ksander, Bruce R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.