Understanding how immune responses affect cancer cell diversity and competition
Mechanisms of immune control of intratumor heterogeneity and clonal competition
This study is looking at how the immune system works with different cancer cells in prostate tumors to better understand how they grow and resist treatment, with the goal of finding new ways to fight cancer.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University New York Stony Brook NIH-funded |
| Lab location | 1 site (Stony Brook, United States) |
| Project ID | NIH-10552000 on NIH RePORTER |
What this research studies
This research investigates how the immune system interacts with different types of cancer cells within tumors, particularly focusing on prostate cancer. It aims to understand the complex relationships between various cancer cell populations and the immune environment, which can influence tumor growth and treatment resistance. By using advanced techniques like lineage tracing and single-cell analysis in mouse models, the researchers hope to uncover mechanisms that could lead to new cancer therapies targeting these interactions.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with prostate cancer who may benefit from novel therapeutic strategies.
Not a fit: Patients with cancers that do not exhibit significant intratumor heterogeneity may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective cancer treatments that specifically target the diverse cell populations within tumors.
How similar studies have performed: Other research has shown promise in understanding tumor heterogeneity and immune interactions, suggesting that this approach could yield valuable insights.
Where this research is happening
Stony Brook, United States
- State University New York Stony Brook — Stony Brook, United States (Active)
Researchers
- Principal investigator: Talos, Flaminia — State University New York Stony Brook
- Study coordinator: Talos, Flaminia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.