Understanding how immune regulation affects chemotherapy response in colorectal cancer
Role of immune regulation in colorectal cancer chemotherapeutic response
This study is looking at how the immune system affects how well the chemotherapy drug 5-fluorouracil works for people with colorectal cancer, to help figure out why some patients do better than others and to find ways to make the treatment more effective.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10916319 on NIH RePORTER |
What this research studies
This research investigates the role of immune regulation in the effectiveness of 5-fluorouracil (5-FU), a common chemotherapy drug used to treat colorectal cancer. It aims to understand why some patients respond well to this treatment while others do not, focusing on the interaction between cancer cells and the immune system. By studying these interactions in immunocompetent models, the research seeks to identify factors that enhance or diminish the drug's effectiveness. The findings could lead to improved treatment strategies that combine chemotherapy with immune modulation.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with advanced-stage colorectal cancer who are undergoing treatment with 5-fluorouracil.
Not a fit: Patients with early-stage colorectal cancer or those not receiving chemotherapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized chemotherapy treatments for colorectal cancer patients.
How similar studies have performed: Previous research has shown that understanding the immune system's role in cancer treatment can lead to significant advancements, suggesting this approach has potential for success.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Lu, Jun — Yale University
- Study coordinator: Lu, Jun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.