Understanding how immune receptors evolve across different organisms
Cross-kingdom health: evolution of innate immune receptors and their targets
This study is looking at how certain immune system proteins have changed and adapted in different living things, like plants and fungi, to help us better understand how our immune systems have evolved over time.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Berkeley NIH-funded |
| Lab location | 1 site (Berkeley, United States) |
| Project ID | NIH-11136650 on NIH RePORTER |
What this research studies
This research investigates the evolution of innate immune receptors, specifically from the NLR protein family, and their role in interactions between different organisms. By analyzing genomic biodiversity, the project aims to uncover how these receptors have adapted and diversified over time, potentially leading to advancements in our understanding of immune system evolution. The research will involve comparative genomics and experimental validation to explore the mechanisms behind immune receptor functionality in various species, including plants and fungi.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to immune system dysfunction or those interested in the genetic basis of immunity.
Not a fit: Patients with established adaptive immunity disorders may not benefit directly from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of immune responses, potentially leading to new treatments for immune-related conditions.
How similar studies have performed: Other research has shown success in understanding immune receptor evolution, but this approach may provide novel insights into cross-kingdom interactions.
Where this research is happening
Berkeley, United States
- University of California Berkeley — Berkeley, United States (Active)
Researchers
- Principal investigator: Krasileva, Ksenia V — University of California Berkeley
- Study coordinator: Krasileva, Ksenia V
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.