Understanding how immune receptors are activated and regulated
Official title: Molecular basis of complement anaphylatoxin receptor activation, regulation, selectivity and signaling bias
Funded at University of Southern California · NIH-11075232 · Data updated 2026-11-12
This study is looking at how certain receptors in our immune system work and communicate with other molecules, which could help us find new treatments for conditions like autoimmune diseases and neurodegenerative disorders, ultimately benefiting patients by improving our understanding of their health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project start | April 15, 2024 |
| Project end | February 28, 2029 |
| Funding year | 2025 |
| Award (this year) | $560,354 |
| NIH project number | 5R01AI182224-02 |
| Project ID | NIH-11075232 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with autoimmune disorders or neurodegenerative conditions, particularly those related to complement system dysregulation.
✕Less likely to help
Patients with conditions unrelated to the immune system or complement dysregulation may not benefit from this research.
What this research studies
This research investigates the molecular mechanisms behind the activation and regulation of complement anaphylatoxin receptors, which play a crucial role in the immune system. By using advanced techniques like cryo-electron microscopy and biochemical assays, the study aims to uncover how these receptors signal and interact with other molecules. Insights gained could lead to new therapeutic strategies for diseases linked to immune system dysregulation, such as autoimmune disorders and neurodegenerative diseases. Patients may benefit from a better understanding of their conditions and potential new treatments.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for autoimmune and neurodegenerative diseases by targeting complement receptors.
How similar studies have gone: Previous research has shown promising results in understanding immune receptor mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Southern California
Los Angeles, United States Active
Researchers
- Principal investigator: Gati, Cornelius — University of Southern California
- Study coordinator: Gati, Cornelius
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.