Understanding how immune receptors are activated and regulated
Molecular basis of complement anaphylatoxin receptor activation, regulation, selectivity and signaling bias
['FUNDING_R01'] · UNIVERSITY OF SOUTHERN CALIFORNIA · NIH-11075232
This study is looking at how certain receptors in our immune system work and communicate with other molecules, which could help us find new treatments for conditions like autoimmune diseases and neurodegenerative disorders, ultimately benefiting patients by improving our understanding of their health.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF SOUTHERN CALIFORNIA (nih funded) |
| Locations | 1 site (Los Angeles, UNITED STATES) |
| Trial ID | NIH-11075232 on ClinicalTrials.gov |
What this research studies
This research investigates the molecular mechanisms behind the activation and regulation of complement anaphylatoxin receptors, which play a crucial role in the immune system. By using advanced techniques like cryo-electron microscopy and biochemical assays, the study aims to uncover how these receptors signal and interact with other molecules. Insights gained could lead to new therapeutic strategies for diseases linked to immune system dysregulation, such as autoimmune disorders and neurodegenerative diseases. Patients may benefit from a better understanding of their conditions and potential new treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with autoimmune disorders or neurodegenerative conditions, particularly those related to complement system dysregulation.
Not a fit: Patients with conditions unrelated to the immune system or complement dysregulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for autoimmune and neurodegenerative diseases by targeting complement receptors.
How similar studies have performed: Previous research has shown promising results in understanding immune receptor mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
Los Angeles, UNITED STATES
- UNIVERSITY OF SOUTHERN CALIFORNIA — Los Angeles, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GATI, CORNELIUS — UNIVERSITY OF SOUTHERN CALIFORNIA
- Study coordinator: GATI, CORNELIUS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease