Understanding how immune memory works in cancer treatment
Official title: Investigating CD4+ T cell memory in cancer immunotherapy
Funded at Washington University · NIH-11144130 · Data updated 2026-11-12
This study is looking at how the immune system remembers cancer and what can help or hurt that memory, so we can create better treatments for cancer patients.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | July 25, 2024 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $178,700 |
| NIH project number | 7K08CA277009-02 |
| Project ID | NIH-11144130 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are cancer patients who are undergoing or considering immunotherapy treatments.
✕Less likely to help
Patients with non-cancerous conditions or those not receiving immunotherapy may not benefit from this research.
What this research studies
This research investigates the mechanisms behind immune memory in cancer patients, focusing on how it can be initiated and disrupted. Using mouse models and patient samples, the study aims to uncover the biological processes that contribute to effective immunotherapy responses. The research will involve advanced techniques such as transcriptomics and clinical trials to gather comprehensive data. By enhancing our understanding of immune memory, the project seeks to inform the development of more effective cancer treatments.
Why it matters
Potential benefit: If successful, this research could lead to improved immunotherapy strategies that enhance long-term tumor control in cancer patients.
How similar studies have gone: Previous research has shown promising results in understanding immune memory in cancer, suggesting that this approach could lead to significant advancements.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Wattenberg, Max — Washington University
- Study coordinator: Wattenberg, Max
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.