Understanding how immune memory cells contribute to allergic asthma
Development of B cell memory in allergic asthma
This study is looking at how certain immune cells called memory B cells behave in people with allergic asthma, to help us understand how they might make allergy symptoms worse and find ways to stop that from happening.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Loyola University Chicago NIH-funded |
| Lab location | 1 site (Maywood, United States) |
| Project ID | NIH-11070298 on NIH RePORTER |
What this research studies
This research investigates the role of memory B cells in allergic asthma, a chronic lung condition triggered by allergens. It aims to understand how these immune cells develop and function in the lungs after repeated exposure to allergens, leading to the production of specific antibodies that cause inflammation and respiratory issues. The study uses a mouse model to explore the characteristics of these memory B cells and their ability to spread throughout the body, potentially worsening allergic reactions. By identifying how these cells operate, the research seeks to find ways to prevent their harmful effects on the body.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with allergic asthma who experience frequent allergic reactions.
Not a fit: Patients with non-allergic asthma or those whose asthma is not triggered by allergens may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce allergic reactions and improve the quality of life for patients with allergic asthma.
How similar studies have performed: Previous research has shown promising results in understanding immune memory in allergic conditions, suggesting that this approach could yield valuable insights.
Where this research is happening
Maywood, United States
- Loyola University Chicago — Maywood, United States (Active)
Researchers
- Principal investigator: Wu, Yee Ling — Loyola University Chicago
- Study coordinator: Wu, Yee Ling
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.