Understanding how immune memory affects inflammation in aortic aneurysms.
Epigenetic Regulation of Trained Immunity in Thoracic Aortic Aneurysms and Dissections
['FUNDING_R01'] · BAYLOR COLLEGE OF MEDICINE · NIH-11168097
This study is looking at how certain immune cells in your body, called macrophages, react to inflammation in conditions like thoracic aortic aneurysms and dissections, and it hopes to find new ways to help treat these issues by understanding how these cells remember past inflammation.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BAYLOR COLLEGE OF MEDICINE (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-11168097 on ClinicalTrials.gov |
What this research studies
This research investigates the role of immune cells, particularly macrophages, in the inflammation associated with thoracic aortic aneurysms and dissections. It explores how these immune cells can 'remember' previous inflammatory stimuli, leading to a heightened response in future encounters. By analyzing the genetic and epigenetic changes in these cells, the study aims to uncover the mechanisms behind this trained immunity and its impact on aortic health. Patients may benefit from insights that could lead to new treatments targeting inflammation in aortic diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with thoracic aortic aneurysms or dissections, particularly those experiencing chronic inflammation.
Not a fit: Patients with aortic conditions unrelated to inflammation or those without a diagnosis of thoracic aortic aneurysms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to novel therapies that reduce inflammation and improve outcomes for patients with thoracic aortic aneurysms.
How similar studies have performed: Other research has shown promising results in understanding immune memory and inflammation, suggesting that this approach could yield valuable insights.
Where this research is happening
HOUSTON, UNITED STATES
- BAYLOR COLLEGE OF MEDICINE — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SHEN, YING H — BAYLOR COLLEGE OF MEDICINE
- Study coordinator: SHEN, YING H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Aortic Diseases, aortic disorder