Understanding how immune injury contributes to aortic aneurysms and dissections
Immune injury as a driver for the development of ascending aortic aneurysms and dissections
This study is looking at how the immune system might play a part in causing serious heart problems like aortic dissections and aneurysms, using special mouse models to better understand how immune cells could affect these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-10646241 on NIH RePORTER |
What this research studies
This research investigates the role of immune responses in the development of acute aortic dissections and aneurysms, which are serious and potentially life-threatening conditions. The researchers have developed two innovative mouse models to study these conditions more effectively, allowing them to explore how immune cell activity may influence the formation of aortic tears and dissections. By examining the presence of specific immune cells in both the aorta and blood, the study aims to uncover the biological pathways that lead to these dangerous cardiovascular events.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of aortic aneurysms or dissections, or those diagnosed with related cardiovascular conditions.
Not a fit: Patients who do not have any history of cardiovascular issues or aortic conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new preventive strategies and treatments for patients at risk of aortic aneurysms and dissections.
How similar studies have performed: While the specific approach of using immune response models for aortic dissections is relatively novel, similar research has shown promise in understanding other cardiovascular diseases.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Jiang, Zhihua — University of Florida
- Study coordinator: Jiang, Zhihua
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.