Understanding how immune genes affect brain development and behavior in youth
Official title: Dissecting neural-immune mechanisms of psychosis and related neurodevelopmental disorders
Funded at University of California Los Angeles · NIH-10996184 · Data updated 2026-11-12
This study is looking at how certain genes related to the brain and immune system affect how kids and teens grow and behave, helping us understand conditions like schizophrenia and other developmental challenges.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | December 8, 2023 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $182,304 |
| NIH project number | 5K01MH135289-02 |
| Project ID | NIH-10996184 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children and adolescents aged 0 to 20 years, particularly those with or at risk for neurodevelopmental disorders.
✕Less likely to help
Patients outside the age range of 0 to 20 years or those without neurodevelopmental concerns may not benefit from this research.
What this research studies
This research investigates the role of neural-immune gene expression in brain development and behavior among children and adolescents. By analyzing genetic data from large-scale studies, the project aims to identify how variations in these genes influence brain growth and function over time. The research will utilize advanced techniques to measure gene expression and its effects on neural development, providing insights into conditions like schizophrenia and other neurodevelopmental disorders. Participants will contribute to a better understanding of how genetic factors can shape mental health outcomes during critical developmental periods.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for neurodevelopmental disorders in children and adolescents.
How similar studies have gone: Previous research has shown promising results in understanding the genetic basis of neurodevelopmental disorders, indicating that this approach could yield valuable insights.
Where this research is happening
-
University of California Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Sharma, Leanna Marie Hernandez — University of California Los Angeles
- Study coordinator: Sharma, Leanna Marie Hernandez
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.