Understanding how immune function changes during sepsis
Official title: Immune Function in Sepsis: Role of Sirtuin
Funded at Cleveland Clinic Lerner Com-Cwru · NIH-11042163 · Data updated 2026-11-12
This study is looking at how the immune system changes in people with sepsis, to better understand the different stages of the condition and find ways to improve treatments and outcomes for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | May 1, 2023 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $362,250 |
| NIH project number | 5R35GM149240-03 |
| Project ID | NIH-11042163 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with sepsis or septic shock who are experiencing acute illness.
✕Less likely to help
Patients who are not currently experiencing sepsis or those with chronic conditions unrelated to sepsis may not benefit from this research.
What this research studies
This research investigates the immune response in patients with sepsis, focusing on how it shifts from an initial hyper-inflammatory state to a hypo-inflammatory state. By identifying specific biomarkers and physiological markers, the study aims to distinguish between these phases of sepsis, which could help tailor treatments more effectively. The research will utilize in vitro assays to analyze leukocyte behavior and its implications for patient outcomes. Ultimately, the goal is to improve the management of sepsis and reduce long-term complications.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for sepsis, potentially reducing mortality and improving recovery for patients.
How similar studies have gone: Previous research has shown promise in understanding immune responses in sepsis, but this approach focusing on phase-specific treatment is relatively novel.
Where this research is happening
-
Cleveland Clinic Lerner Com-Cwru
Cleveland, United States Active
Researchers
- Principal investigator: Vachharajani, Vidula — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Vachharajani, Vidula
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.