Understanding how immune cells use energy in body tissues
Exploring metabolic governance of immune cell form and function
This research looks at how special immune cells called macrophages get their energy to work properly within different parts of the body.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11137642 on NIH RePORTER |
What this research studies
Our bodies have immune cells called macrophages that live in various tissues and play important roles in health and disease. We want to learn how these cells use energy, or metabolism, to develop and function in their specific tissue environments. By using advanced techniques, we can track how these cells process nutrients directly within the body. This helps us discover the unique energy pathways that are essential for macrophages to do their jobs.
Who could benefit from this research
Good fit: This foundational research is relevant to adults aged 21 and older, as it explores basic human biology related to immune cells and body tissues.
Not a fit: Patients seeking immediate direct treatment or intervention for a specific condition would not directly benefit from this early-stage basic research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to target macrophage function, potentially helping to treat a wide range of diseases involving the immune system.
How similar studies have performed: While new technologies have advanced our understanding of cell metabolism, this specific approach to studying immune cell metabolism directly within tissues is novel and builds on initial proof-of-principle findings.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Puleston, Daniel — Icahn School of Medicine at Mount Sinai
- Study coordinator: Puleston, Daniel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.