Understanding how immune cells respond to signals through phosphorylation
Quantitative control of phosphorylation and mechanistic links to immune cell decisions
This study is looking at how immune cells react to different signals in the body, which could help us understand their behavior better and lead to new treatments for patients with immune-related conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-10868612 on NIH RePORTER |
What this research studies
This research investigates how immune cells process various signals through biochemical pathways to determine their responses. By focusing on transcription factors and their phosphorylation dynamics, the study aims to uncover how these modifications influence gene expression and immune functions. The approach combines data-driven and mechanistic modeling to analyze the relationship between signaling events and transcriptional outcomes, which could lead to new insights into immune responses. Patients may benefit from a better understanding of immune cell behavior, potentially informing new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions influenced by immune responses, such as autoimmune diseases or chronic inflammatory conditions.
Not a fit: Patients with purely genetic disorders unrelated to immune function may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for inflammatory diseases by targeting specific immune cell responses.
How similar studies have performed: Previous research has shown promising results in understanding immune cell signaling and its effects on gene expression, indicating that this approach has potential for success.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Gottschalk, Rachel a — University of Pittsburgh at Pittsburgh
- Study coordinator: Gottschalk, Rachel a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.