Understanding How Immune Cells Respond to Severe Injuries
Neutrophils in polytrauma – from recruitment to phenotypic and functional reprogramming
This project looks at how immune cells called neutrophils react to severe injuries, especially in people who also have ongoing low-level inflammation.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project ID | NIH-11120854 on NIH RePORTER |
What this research studies
This research aims to understand how neutrophils, a type of immune cell, respond to severe traumatic injuries. It focuses on how these responses might be different in people who also have chronic low-grade inflammation, sometimes called "metabolic" inflammation. Researchers want to learn how this underlying inflammation changes neutrophil behavior, which can make patients more vulnerable to serious complications like infections and organ failure after trauma. By uncovering these specific mechanisms, the project hopes to find ways to improve recovery and reduce life-threatening situations for patients with severe injuries.
Who could benefit from this research
Good fit: This research is relevant to patients who experience severe traumatic injuries, especially those who also have chronic low-grade systemic inflammation.
Not a fit: Patients without severe traumatic injuries or chronic low-grade systemic inflammation would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies to prevent complications like sepsis and organ failure in trauma patients, particularly those with underlying inflammation.
How similar studies have performed: While the role of neutrophils in trauma is known, understanding how chronic inflammation specifically impacts their response in polytrauma is an area with limited current knowledge, suggesting this approach is novel.
Where this research is happening
Bronx, United States
- Albert Einstein College of Medicine — Bronx, United States (Active)
Researchers
- Principal investigator: De Oliveira, Sofia — Albert Einstein College of Medicine
- Study coordinator: De Oliveira, Sofia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.