Understanding how immune cells respond to infections
Deciphering macrophage versus neutrophil signaling and effector functions in immune responses in vivo
This study is looking at how two types of immune cells help fight infections and control inflammation, using baby zebrafish to learn more about how they work against germs like Aspergillus fumigatus, with the goal of creating better treatments that have fewer side effects for people.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Clemson University NIH-funded |
| Lab location | 1 site (Clemson, United States) |
| Project ID | NIH-11092685 on NIH RePORTER |
What this research studies
This research investigates the roles of two types of immune cells, macrophages and neutrophils, in fighting infections and managing inflammation. Using larval zebrafish as a model, the study aims to identify specific signaling pathways and mechanisms that these cells use to respond to pathogens like Aspergillus fumigatus. By focusing on the distinct functions of these immune cells, the research seeks to develop more targeted therapies that minimize side effects compared to current broad treatments. The approach combines genetic tools and chemical inhibitors to explore how these cells operate during immune responses.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from autoinflammatory diseases or infections caused by pathogens like Aspergillus fumigatus.
Not a fit: Patients with conditions unrelated to immune responses or those not affected by autoinflammatory diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and precise treatments for infections and inflammatory diseases.
How similar studies have performed: Other research has shown promise in understanding immune cell functions, but this specific approach using zebrafish and focusing on macrophage versus neutrophil signaling is relatively novel.
Where this research is happening
Clemson, United States
- Clemson University — Clemson, United States (Active)
Researchers
- Principal investigator: Rosowski, Emily — Clemson University
- Study coordinator: Rosowski, Emily
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.