Understanding how immune cells respond to genital herpes
Mucosal Chemokines and CD8+ T Cell Immunity to Genital Herpes
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA-IRVINE · NIH-10450154
This study is looking at how certain substances in the vaginal area help the immune system gather protective T cells to fight off genital herpes, with the hope of finding better ways to boost the body's defenses against the virus.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA-IRVINE (nih funded) |
| Locations | 1 site (IRVINE, UNITED STATES) |
| Trial ID | NIH-10450154 on ClinicalTrials.gov |
What this research studies
This research investigates the role of mucosal chemokines in the immune response to genital herpes, specifically focusing on how these chemokines help mobilize protective memory T cells in the vaginal mucosa. By studying the mechanisms that control the homing and maintenance of these immune cells, the research aims to uncover new insights into how the body defends itself against herpes simplex virus type 2 (HSV-2). The approach involves examining the expression of specific chemokines and their effects on T cell behavior in a controlled experimental setting. This could lead to improved strategies for enhancing mucosal immunity against genital herpes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have been diagnosed with genital herpes and are interested in understanding or improving their immune response to the virus.
Not a fit: Patients who do not have genital herpes or those who are asymptomatic without a history of HSV-2 infection may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance the immune response to genital herpes, potentially reducing the incidence and severity of outbreaks.
How similar studies have performed: Previous research has shown promising results in understanding immune responses to viral infections, suggesting that this approach could yield valuable insights.
Where this research is happening
IRVINE, UNITED STATES
- UNIVERSITY OF CALIFORNIA-IRVINE — IRVINE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BENMOHAMED, LBACHIR — UNIVERSITY OF CALIFORNIA-IRVINE
- Study coordinator: BENMOHAMED, LBACHIR
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.