Understanding how immune cells respond during mild malaria infections
Modulation of Monocyte and T Cell Functions by Immune Inhibitory Receptors during Subclinical Malaria
['FUNDING_R21'] · CLEVELAND CLINIC LERNER COM-CWRU · NIH-11054872
This study is looking at how certain immune system signals affect the way white blood cells work in kids with mild malaria that doesn’t show symptoms, hoping to find ways to help fight the malaria parasite better.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CLEVELAND CLINIC LERNER COM-CWRU (nih funded) |
| Locations | 1 site (CLEVELAND, UNITED STATES) |
| Trial ID | NIH-11054872 on ClinicalTrials.gov |
What this research studies
This research investigates how certain immune inhibitory receptors affect the function of monocytes and T cells in children with subclinical malaria, which is a form of malaria that does not show obvious symptoms. By analyzing samples from a group of children in Benin, the study aims to uncover the mechanisms that allow the malaria parasite to persist without causing illness. The researchers will focus on specific receptors that may inhibit the immune response, potentially leading to better strategies for malaria elimination. The findings could help improve our understanding of immune responses in malaria and inform future treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 1-15 years who have subclinical malaria infections.
Not a fit: Patients who are not children or do not have subclinical malaria infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for malaria elimination and better management of immune responses in affected populations.
How similar studies have performed: Previous research has shown that understanding immune responses in malaria can lead to significant advancements in treatment and prevention strategies.
Where this research is happening
CLEVELAND, UNITED STATES
- CLEVELAND CLINIC LERNER COM-CWRU — CLEVELAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DOBBS, KATHERINE ROSE — CLEVELAND CLINIC LERNER COM-CWRU
- Study coordinator: DOBBS, KATHERINE ROSE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.