Understanding how immune cells respond during mild malaria infections
Official title: Modulation of Monocyte and T Cell Functions by Immune Inhibitory Receptors during Subclinical Malaria
Funded at Cleveland Clinic Lerner Com-Cwru · NIH-11054872 · Data updated 2026-11-12
This study is looking at how certain immune system signals affect the way white blood cells work in kids with mild malaria that doesn’t show symptoms, hoping to find ways to help fight the malaria parasite better.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | December 19, 2024 |
| Project end | November 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $184,109 |
| NIH project number | 1R21AI182702-01A1 |
| Project ID | NIH-11054872 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 1-15 years who have subclinical malaria infections.
✕Less likely to help
Patients who are not children or do not have subclinical malaria infections may not benefit from this research.
What this research studies
This research investigates how certain immune inhibitory receptors affect the function of monocytes and T cells in children with subclinical malaria, which is a form of malaria that does not show obvious symptoms. By analyzing samples from a group of children in Benin, the study aims to uncover the mechanisms that allow the malaria parasite to persist without causing illness. The researchers will focus on specific receptors that may inhibit the immune response, potentially leading to better strategies for malaria elimination. The findings could help improve our understanding of immune responses in malaria and inform future treatments.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for malaria elimination and better management of immune responses in affected populations.
How similar studies have gone: Previous research has shown that understanding immune responses in malaria can lead to significant advancements in treatment and prevention strategies.
Where this research is happening
-
Cleveland Clinic Lerner Com-Cwru
Cleveland, United States Active
Researchers
- Principal investigator: Dobbs, Katherine Rose — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Dobbs, Katherine Rose
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.